PERISCOPE and PeriCord

Ensayo clínico PERISCOPE

In collaboration with the Blood and Tissue Bank of Barcelona (BST), we have developed a new product for cardiac regeneration called PeriCord. It is a pericardial matrix decellularized and recelularized with umbilical cord mesenchymal cells, specifically, Wharton's gelatin from the cord wall.

Information about the clinical trial can be found in Clinicaltrials.gov

PUBLICATIONS

Roura S, Monguió-Tortajada M, Prat-Vidal C, Gálvez-Montón C, Bayes-Genis A. Our Journey Through Advanced Therapies to Reduce Post-Infarct Scarring. Stem Cell Rev Rep. 2021 May 22. Epub ahead of print.

Monguió-Tortajada M, Prat-Vidal C, Moron-Font M, Clos-Sansalvador M, Calle A, Gastelurrutia P, Cserkoova A, Morancho A, Ramírez MÁ, Rosell A, Bayes-Genis A, Gálvez-Montón C, Borràs FE, Roura S. Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction. Bioact Mater. 2021

Gastelurrutia P, Prat-Vidal C, Vives J, Coll R, Bayes-Genis A, Gálvez-Montón C. Transitioning from preclinical evidence to advanced therapy medicinal product: A Spanish experience. Front Cardiovasc Med 2021 Feb 4; 8:604434.

Prat-Vidal C, Rodríguez-Gómez L, Aylagas M, Nieto-Nicolau N, Gastelurrutia P, Agustí E, Gálvez-Montón C, Jorba I, Teis A, Monguió-Tortajada M, Roura S, Vives J, Torrents-Zapata S, Coca MI, Reales L, Cámara-Rosell ML, Cediel G, Coll R, Farre R, Navajas D, Vilarrodona A, García-López J, Muñoz-Guijosa C, Querol S, Bayes-Genis A. First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft. EBioMedicine 2020 Apr;(54):102729.